Showing posts with label No more us-and-them. Show all posts
Showing posts with label No more us-and-them. Show all posts

Thursday, 9 April 2020

COVID Questions No 5 - How can I help? (Introducing the Zombie Apocalist)

As we enter the depths of the COVID-19 pandemic, most of us are asking, "How can I help?"  Regardless of our trepidation, we recognise the gravity of the situation.  I myself anticipate that over the next few weeks and months, my personal and professional comfort zones will be most likely obliterated.  I cannot expect things to be business as usual.

However, this crisis also presents a unique opportunity for front line clinicians.  We have an urgent need to be pragmatic in our practices.  This need is driven by several factors.
In Paediatric Emergency Medicine, many of us are looking at ways that we can safely achieve a more pragmatic approach to a variety of situations for the benefit of staff, children and their families.  Because COVID-19 has dramatically changed the risk/ benefit analysis for what we do, it is an opportunity to consider what is low risk and low benefit in our usual practice, and find ways of reducing the times when we might previously have observed, investigated or referred.

As it happens, I have had an opportunity to explore this question prior to the COVID-19 pandemic.  I do a great deal of face-to-face education with a variety of clinicians who work in primary care and emergency or acute paediatrics.  In those sessions, I often hear that there is a great deal of variation in practice for certain clinical scenarios.  The clinicians involved make different decisions based on their experience, confidence and the environment in which they work.  It is inevitable for example that a GP working in a remote setting is going to have a different view about referring a patient than someone who sees a similar patient in a city with easy access to a secondary care setting.

As a way of exploring the fringes of clinical practice, I sometimes ask the zombie apocalypse question.  It goes like this: You've just said that you would normally refer this child for a secondary care review.  Now imagine that something has happened that means that there is a risk to the patient from going for that assessment (e.g. zombie apocalypse).  Would you still ask for that further assessment or would you feel that it is safer for the patient to be managed outside of hospital?

Whenever the answer is no, the condition goes on a list of things that need referral no matter what.  In such cases, (e.g suspected meningitis) we are saying that there is a clear need for that referral.  If the answer is that we felt that the change in the risk/ benefit analysis would lead us to a different decision, the condition goes on the zombie apocalist.

Here's a list of the things that commonly end up on the zombie apocalypse list, based on the consensus of the clinicians at various educational events. (Note: all are specific to patients who are children or young people)
[For more detail on the safe assessment and management of each scenario, click on the problem for the link.  If there is no link yet, it will be covered in a post in the near future.]

There are a number of reasons why people are referring or otherwise taking an over-cautious approach to these situations
In each of the situations on the above list, the question that we should ask is, "What will observation, referral or investigation add?"  If any of these actions is primarily intended to add a sense of reassurance for the clinician, we should question that practice in the light of COVID-19 risk.  When I say we, I mean both primary and secondary care clinicians.  If over-caution exists, it can only do so due to a lack of functional teamworking between primary and secondary care.

So when we're asking how can we help with the current crisis, it may not be a case of re-deployment but of adaptation.  One change that could have a significant impact is a renaissance of pragmatism.

My next task is to give a bit more flesh to the pragmatic approach to each of those clinical scenarios.  The posts about each will follow over the next few weeks.  I hope you find them useful in removing the reasons for possible over-caution listed above.  Alternatively, they may simply validate what you are already doing or have always wanted to do but didn't know that it was acceptable practice.

In the meantime, all of the potential drivers of over-caution can also be remedied by a case discussion with an experienced paediatrician.  You should find that your secondary care colleagues welcome the opportunity to allow you to safely manage these scenarios in a pre-hospital setting where appropriate.

Edward Snelson
@sailordoctor


Saturday, 30 March 2019

We should talk more often - Treating CMPA in infants and assumptions between primary and secondary care

It's not uncommon for parents to bring their infant with a feeding problem to an emergency department.  Although that might seem like a problem best managed by a GP or other primary care clinician, it is also understandable that parents seek answers wherever they can find them when their baby seems to be constantly miserable.

The natural tendency of many infant presentations to self-resolve (colic, mild reflux etc.) means that rather than always medicalise the situation, watchful waiting is often the best strategy.  If the problem is non-IgE cow's milk protein allergy (CMPA) then delay in intervention leads to prolonging the infant's misery.  Getting the balance between overdiagnosing CMPA and avoiding a delay in diagnosis is not easy.  It involves careful history taking and thorough examination alongside a sympathetic but objective approach.

During this process, it is common for parents to feel that they are not being taken seriously or that no-one is doing anything.  The reality is almost certainly that they are being taken seriously and that a lot of work is being put in by the clinician seeing them.  However, it can be that the parent feels that they are no further forward and so come to the Emergency Department (ED) to seek what they percieve to be a more specialist opinion.

If an infant genuinely does have non-IgE CMPA, that diagnosis will rarely be made at first presentation because the symptoms are too vague and non-specific.  Gastro-oesophageal reflux disease (GORD) is more common and in many cases this is the presumed diagnosis for the miserable infant regurgitating some of their feeds.  The diagnosis of CMPA is often not made until the third or fourth attendance.  This is entirely reasonable since it takes time to establish a pattern of symptoms and to consider other possible diagnoses.

Let's imagine that the third or fourth time that the parents of a formula fed infant seek help is the time they go to the ED.  They are seen by one of the doctors and that person thinks that on balance, management as possible CMPA is the logical next step.  What should that clinician do - change the milk or send them back to their General Practitioner?  This question of who should do what is an interesting one that causes much debate.

There are plenty of arguments for the ED clinician to make the change.
  • The ED clinician has decided that they think it is the right thing to do.  There is an ethical mandate to either do it or facilitate the change in milk.  Sending the parents away without making the change themselves poses a risk.
  • Changing the milk avoids some duplication of work for the GP.
  • There is no guarantee that the parents will be able to get an early appointment with their GP and any delay might mean unnecessary suffering for infant and parents.
There are also arguments against the ED clinician changing the formula:
  • Assuming there has been some continuity at the GP end, the GP will have a better idea of the full picture rather than just the one presentation to the ED.
  • By changing the milk, there is potential to undermine the GP ("My GP did nothing but the hospital diagnosed and treated...") and reinforce the belief that the ED is the place to go for everything.
  • There is a possibility that by doing so, the GP's equally valid but slightly different plan is derailed.  Once the change is made, it is extremely difficult to undo that change.
We want the infant to have the right treatment in a timely way but we also know that it is in everyone's interest that we don't end up undermining the relationship between that family and their GP.

Another factor that affects the decision is the uncertainty that is brought about by the primary-secondary care divide.  Each group will tend to have its own opinion about the best way forward.  Due to a woeful lack of converstaion between primary and secondary care, there are often assumptions made rather than actual converstions about such matters.  In the digital age, there is no real excuse for a lack of discussion about these things so I decided to ask both sides what they thought.

First of all I asked the primary care community what they thought should happen.  Three quarters thought that the ED clinician should change the milk.  About a quarter thought that the child should then stay under secondary care.  Another quarter wanted to retain control of the decision making in primary care.
Next I asked the EM community what they thought they should be doing.  The results were remarkably similar.
I found that very interesting.  While there was no overwhelming consensus on the best action in these cases, there was good agreement and certainly nothing that could be described as opposite views.  As well as suggesting that changing the formula and returning the child to the care of their GP is likely to be the most acceptable way forward, it shows that there may be times when the assumption that the two communities will have very different views will be wrong.

There are many percieved differences between the views of primary and secondary care clinicians.  If we go about it the right way, we might be able to explore those perceptions in a functional and constructive way.  We might better understand the differences in approach if they do exist and learn from each other.  We might, as in this case, find out that the imagined differences are not all that real.  Of course, done badly, it will end up with upset and opposition.  Let's not do that - we're all on the same team.  Whatever we do, we should come at these discussions with positivity and an open mind.  In the era we are in, there is no good reason to allow percieved differences to remain unchallenged or unresolved.

Thanks to everyone who took part in both polls.  If you have any other suggestions for similar issue that could be explored, let me know (post in comments below or contact me via social media).

We should definitely talk more often.

Edward Snelson
Assumptionologist
@sailordoctor

If anyone is wanting to get involved in the conversations on Twitter but feels cautious about it, there was a great guide written recently by the Don't Forget the Bubbles team which would be useful for anyone who would apprectiate a little guidance in what to do when starting up on Twitter.

Leo, G. Don’t Forget The Twitter, Don't Forget the Bubbles, 2019.
http://doi.org/10.31440/DFTB.18310



Monday, 11 June 2018

Paediatrics is Not a Specialty - top tips for working with young people

Paediatrics is difficult to define as a specialty.  At one point the RCPCH talked about “doctors who look at specific health issues, diseases and disorders related to stages of growth and development.”  Now the RCPCH careers site has a very different note stating, "Whether a paediatrician, GP, children's nurse or pharmacist, our job is to help babies, children and young people thrive." I'm guessing that the RCPCH realised that it wasn't just doctors and it certainly wasn't just paediatricians who fitted the original description.

In fact paediatrics may not be a specialty at all.  It could be defined as the art of treating children differently from adults by knowing what diseases affect them, how they respond to illness and how to use that knowledge to help them during their illness or prevent them from becoming ill.

Anyone who works with children in a healthcare setting should study of the art of paediatrics.  We all need to develop our skills in assessing and treating ill children as well as becoming experts in all the other aspects of child health including safeguarding, growth and development.  Children and young people are different in so many ways and it takes a bit of effort to get good at working with them but it is completely worth it.

What is different about children and young people that requires a different approach and different skills?

Children respond differently to illness - Physiological changes can be dramatic in uncomplicated viral illness making the recognition of complicated infection difficult
Children may not localise, report or recognise symptoms - This is why constipation and UTI are often only diagnosed when they have been prolonged.
Children often present with something normal - This often happens because an adult is concerned and doesn't know that the symptom is normal.  One example is knock knees in children.
The overall likelihood of significant pathology is low - Much of paediatrics is about diagnosing normality or at least that the illness is uncomplicated and does not require medical intervention.  The other side of this coin is that the routine nature of a good outcome can lead to complacency and impairs our awareness of complications and significant pathology.
Children are vulnerable - As well as the safeguarding element of caring for children and young people, we have to consider how difficult it is for them to feel safe in a healthcare setting.  It is confusing and intimidating and it is too easy to forget to keep the child at the centre of the process.
There is a lot of uncertainty that goes with the assessment of children - paediatrics is often compared to veterinary medicine because we end up relying more on what we see.  It is fairly usual to find that we can't get specific symptoms and that our ability to examine is limited by the child's interaction.

Last week, I went onto TwitFace and asked the people who were online what their top tips are for working with children an young people.  What follows is based on some of the great responses I recieved.

Starting with the general advice:

There were also loads of tips for examining children:
I haven't been able to include everything and in some cases there were recurring themes which I have categorised together.  There were quite a few specific things that people have found to be useful in paediatric examination, some of which are listed here:
  • The guess what's in the tummy game.  I have a high success rate with guessing sausages.  However you go about it I would highly recommend this approach to abdominal examination.  It's probably quite scary for a child to have a stranger press their tummy, but if it's a game that seems to be a different matter.
  • For assessing gait, get the child to walk towards their parent rather than away from them.
  • For ENT examination:  Tell the child: "I have a magic fairy/dragon detector (ear thermometer) that goes beep when a fairy is in the room. If it beeps I have to check their ears and throat with my magic torch to make sure it isn’t hiding in there."  I have to try that one.
  • For respiratory exam, ask them to blow out the candles on an imaginary birthday cake.
One place even had a departmental rabbit.  I can imagine that would work to settle many an otherwise inconsolable child!

Paediatrics may not be a specialty but it is an art.  How you approach that art is up to you but whichever you go about it the end result should be the same:  The child will get the best care possible and you might be having some fun at the same time.

Edward Snelson
Possibly not a Paediatrician
@sailordoctor

Disclaimer - All the views expressed here are solely those of the author.  Any references to Royal Colleges are entirely fictional and should not be used as a reason to revoke the author's invitation to the annual RCPCH cheese night.

Acknowledgements: Thank you to all the people who shared their tips and tricks via social media or face to face.  More importantly, thank you to all the children who put up with us while we figure out how to do the whole paediatric examination thing.  Your patience and tolerance is appreciated.



Thursday, 18 January 2018

Investigations in Bronchiolitis - Help a Brother Out

One of the things that a crisis should do is to bring people together.  As the UK's National Health Service experiences a winter that is bringing  it to it's knees, we should be more aware than ever that Primary and Secondary Care need to work together as a team so that we all come out the other end of this intact.  There are those in each camp that are so entrenched in the us-and-them mentality that this idea of teamwork is against  their very being.  If you think that General (family) Practitioners (GPs) are lazy idiots or you think that hospital doctors are arrogant and lack communication skills, I'm not sure that I've got anything to help you.  (Perhaps a hug?)  If you are willing to believe that we are all part of a team and that any divisions are both understandable and resolvable, read on.

The issues that cause division are (in my experience) usually due to misunderstanding and a lack of insight into the part that we play in creating these disparities.  The irritations that I cause my colleagues, whether in Primary or Secondary Care, tend to be completely unintentional.  Sometimes it can be what seems like the smallest thing and I have no idea of the impact it has on someone else.  That's why it's so important to talk to each other.

Let me describe an example: the seemingly simple act of requesting a chest X-ray for a baby with bronchiolitis.

Bronchiolitis is usually a set piece.  An infant, usually under 12 months old, gets inflammation in their airways during a viral respiratory tract infection.  This leads to a three to five day period of increasing symptoms that usually consist of cough, wheeze, difficulty feeding and increased work of breathing.  In practical terms, that might play out like this:

Monday - A three month old is snotty and coughing but well and feeding nicely.  Breathing will probably be normal at this stage.

Tuesday - The parents have now noticed some noisy breathing and that feeding isn't as good as it normally is.  like many people in these circumstances, they seek a medical opinion and so go to their GP.  They are seen and the diagnosis of bronchiolitis is explained.  The clinician advises frequent small feeds and gives safety-netting advice for what to look out for in case this child becomes one of the very small minority who develop breathing or feeding difficulties that require support as an inpatient.  In keeping with NICE guidelines (1), they do no tests and give no treatments.

Wednesday - The parents have noticed a slight worsening of the feeding and are unsure about whether this is bad enough to need something to be done.  They hold off doing anything during the day but when their baby refuses an evening feed they take their precious bundle to the local emergency department.  There the child gets a thorough assessment.  Clinically the infant is well hydrated and although they have wheeze and mild recession they are looking happy and have oxygen saturations of 95% in air. Despite the earlier feed refusal, they now take 100 mls of milk. The assessing clinician hears a few crackles in the chest and decides to do a chest X-ray, just to be sure that today's worsening symptoms are not due to a bacterial pneumonia developing.

When is it necessary to do a chest X-ray for babies with bronchiolitis?

There are many possible complications of bronchiolitis.  In theory, these should be apparent on a chest X-ray.  There are also conditions that mimic simple bronchiolitis, most notably congestive cardiac failure.  So, a chest X-ray seems a sensible thing to do to add value to the assessment.  Except that it doesn't, for two main reasons.

These are the reasons why a chest X-ray doesn't add value to the assessment of a typical presentation of bronchiolitis:

  • There is always something to be seen on the X-ray.  If you are looking for normal, you are unlikely to find it.
  • If the infant has bronchiolitis, that is enough explanation for their clinical condition.  If they had a complication such as lobar pneumonia as well, you would't be doing the chest X-ray to see if there is a problem, you'd be doing it because the child is seriously unwell.

Coming back to our little one with bronchiolitis, let's assume that the chest X-ray shows what it always shows in bronchiolitis - something of uncertain significance.  There will be a little fluffy shadow somewhere due to the mucous plugging and atelectasis that is part and parcel of bronchiolitis.  Often, there is something to be seen at the right heart border (or as a wise radiologist once redefined for me: "the area of radiological romance") which may or may not be something.  Once seen, it is very difficult not to feel the need to treat for possible bacterial infection.  This brings me on to the next few reasons for not doing a chest X-ray.

Doing a chest X-ray in bronchiolitis is associated with increased antibiotic prescribing rates.  Bacterial superinfection in bronchiolitis is rare and is usually clinically apparent.  Bronchiolitis is reason enough to have respiratory symptoms.  If a baby also develops pneumonia, they are usually quite unwell and have a marked degree of distress.  So, following that logic, for our baby the antibiotics are simply unnecessary, in which case they may do harm.  Since one of the problems that comes with bronchiolitis is feeding and hydration, why give these babies a gastric irritant?

Finally, there is a second victim here: the clinician who saw the baby on Tuesday.  Despite sterling work by the GP, the parents are likely to believe in retrospect that they were given a poor service.
All the evidence is there:

  • The person that they saw in the community did nothing and their child became worse.  
  • The experts in the hospital did a test which showed that their baby needed antibiotics.
  • Antibiotics were given and eventually the bronchiolitis got better. 

Why didn't the GP do something when we went the first time?

Of course both clinicians in this story were trying to do their best for the patient.  Neither of them had anything on their mind other than trying to ensure the best outcome for the child. There was no disrespect intended and no one wanted to cause anyone any problems.  We are all just trying to get through the day and to keep our patients safe and well.

Thankfully, it turns out that in bronchiolitis, keeping your patient safe and well is probably best done without the use of chest x-ray and antibiotics.  So, we in Secondary Care can help our colleagues in Primary Care out by making the assessment that needs to be made: in or out (of hospital)?  That decision is made on clinical grounds and if they need to be admitted, a chest X-ray may be useful.  Maybe.

Edward Snelson
Vice President of the Guild of Doing as Much Nothing as Possible
@sailordoctor

Disclaimer:  I did a chest X-ray for bronchiolitis once.  There was a white patch at the right heart border but it turned out to be tippex on the screen.

Reference

  1. Bronchiolitis in children: diagnosis and management, NICE guideline [NG9] Published date: June 2015



Wednesday, 12 April 2017

Henoch Shonlein Purpura - Who, What, Where and When?

In Paediatric Emergency Medicine in the UK, it is often the case that a referral requires me to choose between more than one specialty.  For example cuts on the face (the ones that require suturing under general anaesthetic) could be referred to either plastic surgeons or maxillofacial surgeons.  Hand fractures are sometimes looked after by the orhopaedic surgeons (note use of their Sunday name) and sometimes by plastics.  Now that I think about it, the overlap almost always involves plastic surgery.

The decision about who to refer a patient to will depend on various factors.  These include resources, availability and the particulars of the case.  Matching the child and the illness (or injury) to the right person to follow the case up is part of the art of Primary Care.  After much thought and consideration, I've decided to refer children with Henoch Schonlein Purpura (HSP) to the very best.  I refer them to their General Practitioner.  
(Ankle bracelet not included.  See in store for more details)

The reason for this is that General Practice does two things better than any other specialty.  General Practice excels at avoiding the harm done by unnecessary tests and treatments, and (in my opinion) no other specialty in medicine is so good at providing the continuity needed to monitor a condition.  This allows the patient to receive appropriate care while at the same time having an experienced clinician involved who will intervene if needed.  For uncomplicated HSP, that is exactly what is needed.

HSP is the most common vasculitis in children.  Nobody really knows why children get it but the number one suspect is of course 'recent infection'.  These are always getting the blame for mysterious childhood illnesses.  If you ask me, I think it is institutional infectionism.

HSP is best known for causing a purpuric rash on the buttocks and lower limbs,  While this is the typical rash, atypical rashes are pretty common.  The thing that is most consistent about the HSP rash is the following triad:

HSP is a clinical diagnosis.  It is usually identifiable through a typical presentation and because other possible causes of non-blanching rash can be ruled out clinically.  Sepsis, leukaemia and immune thrombocytopaenia are some of the possibilities that should be considered if the presentation is not that of typical HSP, or if the child is unwell, or anaemic or has splenomegally (etc. etc.).

It is also worth mentioning that not all children have the courtesy to present with their symptoms in the correct order.  Everyone know that the rash should come first.  Some children choose to ignore this and complain of aches and pains before the rash appears.  Also, before the rash becomes purpuric it can start out as non-specific erythema or even look a little urticarial.

I am often asked if blood tests are needed for a child when diagnosing HSP.  My answer is this:  
For example, I don't do CRPs to diagnose sepsis.  I use a CRP once I have diagnosed sepsis because that will help in the ongoing management.  In injury, I use X-rays where it is probable that the X-ray will alter my management.  I don't use CXR to diagnose pneumonia.  I use CXR if I suspect complicated or atypical pneumonia.  In HSP diagnosis, tests are really for uncertainty in those cases where the presentation is ambiguous or atypical.  If the presentation is unambiguously HSP, no diagnostic tests are needed.  There are tests to be done but those are screening for complications.

Most cases of HSP follow a benign course.  The rash persists for several weeks and there many children experience aches and pains in their legs and abdomen.  However, symptoms other than the rash will typically settle in the first week or couple of weeks.  Things don't always go this way though.  There are four possible ways for the course of HSP to be problematic.

Problem 1) Extreme symptoms.

Pain is a funny thing and in some cases of HSP, despite a lack of significant complications, some children and young people get severe pain (despite good doses of simple analgesia) in their legs or abdomen.  These children should be referred acutely to be seen by a paediatrician.  This is both to enable management of the pain and to look for more significant complications.

Problem 2) Non-renal complications of HSP

I've said that leg and abdominal pains are fairly common symptoms of HSP.  It is also true that everything in paediatrics has an evil twin.  In the case of leg pains, it is possible for HSP to cause a significant polyarthritis.  If a child has swollen joints, the pain is severe or they develop a significant limp - refer.

Similarly, if a child with HSP shows signs of severe abdominal pain, consider the possibility that they have developed one of the most significant complications of HSP - intussusception.  Other signs might include pale episodes and blood or 'redcurrant jelly' in the stools.  With or without these other signs, assessment by a paediatric surgeon is urgently needed if abdominal pain becomes acutely severe.

Almost anything that can go wrong can go wrong in HSP.  Involvement of other organs than kidneys, skin, bowel and joints is rare.  Atypical symptoms such as headache or chest pain should be taken very seriously and the child should be referred acutely.

At some point, all of these factors will lead to a decision about where the child is managed.  I think that the decision usually looks like this:
There is nothing mandatory about referring a clear cut case of HSP at first presentation.  However, most GPs that I know would prefer an initial assessment in secondary care, even if the child is extremely well and has no symptoms with their non-blanching rash.

Problem 3) Renal complications

While aches and rashes are what cause children and parents to lose sleep over HSP, it is the possibility of renal complications that usually worries the clinician.   A significant chunk of children who have HSP will develop a mild nephritis.  A smaller number go onto get a significant nephritis and a small number develop severe, kidney-threatening nephropathy.  Don't worry too much about the numbers as they don't really help in a case series of one.  What is true is that it is very likely that the child in front of you will either never develop a renal problem, and if urine dip flags something up, it is most likely to be a transient mild haematuria or proteinuria.  In order to identify those cases of silent but significant nephritis, monitoring is needed for all cases of HSP.

Exactly how much monitoring is needed is slightly unclear.  Advice is based on clinical experience, common sense and a bit of logic.  If you put those things together, you might come up with this:
This is followup strategy is based on the well child, who has no significant haematuria or proteinuria at any point.

What this aims to do is detect renal involvement early, while avoiding any OCD type behaviour (such as daily urine dipsticks).  The length of follow-up is debatable but is based on a cohort study that showed that no child with HSP developed renal involvement after 6 months.  Roughly half the guidelines from big centres recommend follow up to 6 months and half say 12 months.

There are those that advocate longer followup (including lifelong annual reviews) for all cases.  However, I suspect that there is a significant effect of bias driving that.  If a child has had a complicated case of HSP, this may well be warranted, but if the course of the illness was benign I doubt that they will develop late complications.  The Nottingham renal unit recommends lifelong monitoring if everything else has been normal but there was at least one occasion where the urine dip showed ++ or more of protein. (1) This stratification allows for the possibility of nephropathy in selected cases rather than ongoing screening for all.

The need for a blood pressure check after the first couple of visits is also debatable (thus the *).  By continuing to check BP after it has been normal on two occasions, are we saying that the child could have had renal involvement severe enough to cause hypertension, yet this never showed up as a positive dipstick?  This seems very unlikely to me and I have never found a paediatrician who has seen such a thing happen.  Despite this, all guidelines and review articles that I have seen recommend that BP is checked at every visit.

Problem 4 - Prolonged or relapsing course of illness

This brings me neatly onto the final thing that might cause a clinician to feel that the child needs more investigation and management than can be given in Primary Care.  In some cases, the course of HSP does not follow the typical one of a few weeks of rash and a few days of other symptoms.  The symptoms might continue for months, or relapse after initial remission.  A mild relapse is actually quite a common occurrence in HSP and worth warning the family about.  If a relapse is severe or prolonged I would suggest that these children also need to be referred.  The paediatrician will need to review the diagnosis (in case the reason for an atypical course is that the diagnosis is wrong) and consider whether to investigate e.g. for an autoimmune cause of the rash.

HSP FAQs

Q. Does the child need blood tests at presentation?

A. Only if there is diagnostic ambiguity or if the urine dip/ BP is abnormal.


Q. Do steroids prevent complications?

A. No, but they may have a role in treating complications of HSP. (2) Other interventions that have found to be unhelpful include antiplatelet treatment or immunosupression.


Q. What counts as hypertension in a child?

A. This is difficult question to give a straight answer to.  It's not a lack of people coming up with definitions that is the issue.  It's more that we don't know much about what levels of hypertension cause what effect in the long term.  Most guidelines go for something like systolic BP >95th centile on three occasions.  It is important to use the correct size of BP cuff for the size of the child and to use an appropriate reference range. (3)


Q. So should I be checking BP at every visit even if the urine has been normal (no more than a trace of blood and no more than + protein) on every test?

A. If you didn't, you would be going against all the guidelines in existence.  I still haven't had a good explanation as to why it is really necessary, but nor have I convinced others that it is unnecessary, so for now you should keep on doing it.


So in summary, managing HSP is relatively straightforward.  After initial assessment, most can be monitored by their GP.  Some will need to stay under the care of a paediatrician and a small number will need to be referred on, usually to a nephrologist.  For the uncomplicated cases, there is no absolute certainty about often or how long to screen for renal involvement, so guidelines have to be mostly based on pragmatic expert opinion.

So, who, what, where and when?  Me, you and maybe them doing as much nothing as possible until we are sure that everything is OK.  Simple really.

Edward Snelson
Dogmatologist
@sailordoctor


I would like to express my deepest gratitude to the young person who consented to have photos of her HSP rash used for this purpose.  Thank you.


References
  1. Henoch-Schönlein Purpura (HSP) Guideline, Nottingham Children's Hospital
  2. W Chartapisak et al., Prevention and treatment of renal disease in Henoch-Schönlein purpura: a systematic review, ADC, Feb 2009
  3. Blood Pressure Levels for Boys by Age and Height Percentile, National Heart, Lung and Blood Institute


Tuesday, 28 March 2017

The Random Goldfish - When confirmation bias met affective bias


In the previous post, I explored how confirmation bias can lead us to believe that something is causing a problem when really it isn't.  Although sometimes unexpected, this kind of news is not unwelcome.  Finding out that fever doesn't really cause febrile convulsions is a surprise to many, but usually a good one.  Telling people that their treatments don't work is much less popular.

Anyone who has been a clinician for a reasonable amount of time knows what it feels like to share good and bad news with someone.  When I am teaching about paediatrics in primary care, it sometimes feels like I am saying that very few treatments actually work.  This feels having something taken away form us.  The real headline is that children make themselves better in the vast majority of clinical scenarios.  It is our job as clinicians to do as much nothing as possible while looking for opportunities to give effective treatments.

One question that I am often asked is, "If these treatments don't work, why do people use them?" Good question.  I tend to assume that my sample cohort of co-workers is representative of clinicians and I work with good, conscientious people who want to give children the best treatment possible. Since I don't believe that clinicians are generally unintelligent, malicious or lazy, I will take a risk and say that there must be powerful forces at work if any of us are giving ineffective medicines to children.  The problem that leads us all to use ineffective treatments is our very desire to make children better and parents happy.

If you want something really badly and do something in an attempt to make it come about, when the thing happens, we are likely to believe that this was cause and effect.  This approach would work in a fixed environment,  For example, consider a person trying to solve a puzzle (like a Rubik's Cube).  The puzzle isn't going to solve itself, so if the person tries many different strategies and then something works, they have solved the puzzle.  This assumes that the puzzle has not been solved by chance, which in this case is extremely unlikely.

Now consider someone with a different problem.  He wants a picture of his goldfish next to the castle in the goldfish bowl.  He tries shining a light to get the goldfish to move into position.  He tries tapping the glass, placing some food and tries making waves in the tank.  Whatever he does just before the goldfish moves into position must have done the trick right?  Wrong.

Well, much of paediatrics is like that.  Childhood symptoms often fluctuate or resolve.  We want our treatments to work.  We want to make children better and parents to be happy.  These factors are the perfect ingredients for us to wrongly believe that what we did worked.  Sometimes though, the goldfish just moves.  Because it's a goldfish.

Enough about goldfish. Let's use a really common example of how confirmation bias leads us and our patients to believe in an effect that is not real.

If I tell someone that antibiotics will cure a child's throat infection within a week, you can imagine how that sounds plausible.  Then, the initial belief in my statement will be reinforced when the child does indeed get better.  The true believer does not consider that the alternative is just as plausible - that all (uncomplicated) throat infections get better with time.  You know that guy who still has the viral sore throat he caught when he was two years old?  No?  Neither do I.

Paediatrics is a branch of medicine where most illnesses will resolve with time and many symptoms that could be attributed to a treatable cause.  But we and the parents both want the problem to be treatable.  The problem is, you're too nice.  You want to help and you want everyone to leave happy. This is called affective bias (the thing that reinforces confirmation bias). The end result is that we can easily believe that we are treating a problem, when in fact it gets better on its own.


Now, bias gets a bad name in medicine, but I would like to defend bias.  Clinicians could never learn or make decisions without bias.  We would be permanently uncertain and unable to choose. Without confirmation bias, we would never notice a pattern.  Without affective bias we would never take the parents seriously or care about the child.

Bias is good.  There, I've said it.

Bias is your friend, but friends can be fickle.  The thing about friends is that despite their faults, they're still your friends.  It is good to know what to expect from them.  That way, you don't feel surprised when they do the thing that they always do.  In the case of bias, your friend wants to mislead you and get you do do things you shouldn't do.

So, what are the best examples of the confirmation bias of presumed effect in paediatrics?  I've already mentioned antibiotics for upper respiratory tract infection.  There are many more, but lets just look at one in detail as an example:

Confirmation bias (presumed effect) - 
Example number 2: Treatments for gastro-oesophageal reflux disease in infants
If there was ever a paediatric condition that fitted the brief for this subject, it is feeding problems in babies.  The symptoms that babies present with are so often simply withing normal limits for infancy.   Did you know that straining is a thing that 1 in 6 babies do and that it is called dyschezia, not constipation?  If you add regurgitation of milk (aka 'reflux'), colic and other common gastrointestinal complaints, most babies have some sort of symptom that we could treat if we chose to during the first few months of life.  With a few exceptions, these are normal for being a baby, and will resolve in time.

The cardinal sign of a self resolving problem is that there are treatments available without good evidence of efficacy.  (Cough medicines for children are a good example of this.)  By way of contrast, there are very few treatment strategies for the management of pneumonia.  I'm guessing that you probably use antibiotics.

The evidence for the available treatments for reflux disease is not good.  In many cases the evidence is that they have little effect.  Rather than posting several dozen references, I am simply going to signpost you to the NICE guideline for Gastro-oesophageal reflux disease in children and young people. (1)  In the full document there is an extensive literature review which makes for interesting reading.  The bottom line is that the evidence is usually lacking.  The evidence that we do have form research points toward little or no effect for alginates, H2 agonists and PPIs.  By their own admission, much of the advice in the guideline depends on the experience of the experts involved in the guideline writing process.

Of course the problem is that there are infants with genuine pathology.  These children often begin their visits to healthcare professionals with non-specific presentations which easily fit the bill for what is 'normal for infancy'.  If we are honest with ourselves, the niggling doubt that the child might have a significant problem is one of the factors that pushes us in the direction of pulling out our prescription pads.  After all, it won't look as bad when the child turns out to have a problem later if we were busy trying treatments instead of reassuring the parent that these symptoms are usually part of normal infancy.

Avoiding unnecessary treatments is gold standard care.  Alginates are the most frequently used medications for reflux symptoms but in my experience this treatment runs a high risk of causing constipation.  This is far from ideal if you are trying to make life easier for baby and parent alike.   Motility drugs have repeatedly been associated with dangerous cardiac side effects and PPIs have been shown to increase the risk of respiratory tract infection. (2)  The take home message from this is that, although medication is an option, we need to be sure that a treatment is really likely to be better than watchful waiting.

The NICE guidelines focus on consideration of how the infant is affected - severe distress or red flags (faltering growth, feed refusal etc.).  It is also important to consider other possible diagnoses such as UTI.

I said that there were quite a few problems that have a similar story.  Going through all of them in detail would take a long time, but here is a list of some of the treatments that lend themselves to this combined bias effect:
The evidence for all of these treatments in children is that they work rarely (antibiotics for URTI, inhalers for cough alone, suspected CMPA based on colic alone) or never (cough syrups, simethicone or lactase for colic in babies).  All of these clinical scenarios share a common theme- the likelihood that the symptom will resolve in time.

So lets come back to bias.  Confirmation bias will cause us to believe that a treatment is effective while affective bias will make us want to give something even when there is little or no benefit. "But earlier, you said that bias is good.  You said that bias is my friend!" you might well say.  I stand by that.  As long as you know how you expect your friends to behave, any misbehavior can be managed and they can still be your friends.

For confirmation bias, we need to have good evidence to justify treatment that is used for symptoms when the natural course is resolution with time.  For example, I don't need evidence to back up my belief that morphine works for pain when a child has a broken leg.  If the child feels less pain afterwards, it has nothing to do with a goldfish effect.  Conversely, I should want evidence that a treatment is effective for any of the symptoms listed above.

For affective bias, we need to harness our desire to be nice to parents and children.  That means not wasting their time with ineffective treatments or worse still causing new problems. Sometimes, doing nothing is the nicest thing that you can do.  Managing to treat where appropriate and avoid unnecessary treatment is the holy grail of paediatrics.  Ultimately, the child is the patient and we need to only give them medication that is more likely to help than harm.  At least, that's what we should be trying to do despite our biases.

Edward Snelson
Amateur Medical Errorist
@sailordoctor

Disclaimer - I am too biased to be taken seriously, even by myself.



References
  1. NG1 - Guideline for Gastro-oesophageal reflux disease in children and young people, NICE
  2. Orenstein et al., Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease, J Pediatr. 2009 Apr;154(4):514-520


Wednesday, 3 February 2016

Who should write your guidelines? Sepsis and the happy GP

In January 2016 NICE announced the consultation period for the draft guideline about sepsis and soon afterwards a sad news story hit the headlines.  The story was about a boy who had tragically died of sepsis.  There is a temptation to allow such emotive events to be drivers when writing guidelines but this needs to be balanced by considering the effect of any referral or treatment threshold on the whole population of children presenting to GPs and EDs.


As a user of guidelines, I would like to explore the complexities of any protocolised approach to recognising sepsis.  There are elements of the process that are simple, and elements that are less so.

First of all, let me be clear.  I welcome a guideline that aims to raise the awareness of clinicians to the possibility that a child may have sepsis.  I welcome the push to speed the diagnosis and shorten the time to receiving intravenous antibiotics.  However, greater sensitivity usually comes at the cost of poorer specificity.  In this case that probably means referring more well children and treating more well children in hospital.  That does not just have implications for the workload of emergency departments and inpatient wards.  It also affects every child who did not have sepsis but was flagged up on the flowchart as being high risk.  Referral to hospital and admission as an inpatient both have an associated morbidity.  We need to be careful not to repeat the bronchiolitis admission effect. (2)


In a recent BMJ, there was an article about why Dutch GPs are happier.  One of the reasons given was that Primary Care write their own guidelines in Holland.  In the UK, guidelines are more often developed in a more secondary-care-centric fashion.   I wonder whether having Primary Care take the lead on writing their own guidelines would help avoid the over-diagnosis effect.

What would a guideline for sepsis look like if it was being written by GP’s for GP’s?  I think it might look a bit like this…

  • Always consider sepsis if a person presents with signs or symptoms that indicate possible infection.  In primary care the presumption is that the febrile patient is unlikely to have sepsis.  However a small proportion do and detecting this requires vigilance.
  • Finding a simple explanation for signs and symptoms does not mean that a person does not have sepsis.  The possibility of sepsis is less about the specifics and more about the severity of signs (such as tachycardia) and symptoms (such as feeling very unwell or being significantly affected by the illness).
  • Be especially thorough if a patient or parent is especially concerned or attends repeatedly for the same illness.  This does not necessarily indicate sepsis but should prompt a thorough re-evaluation of the patient’s wellness.
  • Be aware that communication difficulties put patients at higher risk.
  • Be aware of high risk groups and have a lower threshold for referral.
  • The seriously unwell patient is usually easy to recognise.  The difficulty lies in recognising the patient who is in the early stages of sepsis.  It is also these patients who are the most likely to benefit from early recognition.
…or something similar.

I think that most of that would be agreeable to most clinicians.  After that, I find myself struggling to agree with myself over the nitty-gritty of the what to do when in each circumstance.  The reason for that is that there are so many common scenarios that make a sepsis pathway virtually impossible to write.  Some of these scenarios are the post immunisation baby with a fever, the six month old with bronchiolitis and tachycardia and the 2 year old with viral wheeze.  Each of these cases bring an interesting sensation to the mix.  I inherently feel that sespis is much less likely in these children and yet each will be spat out of my decision tool with a tequila coloured label of some kind.


What is the solution?  I feel that sepsis guidelines need to promote the rule-out value of wellness.  Wellness seems vague but it is really a combination of gestalt (gut feel) and what we see a child do.  Gestalt is valid as long as it is built on plenty of valid clinical experience.  What we see a child do is valid because when a child smiles and plays, it tells us that the frivolous centres of the brain are perfused and not toxic.

Will wellness be in your sepsis guideline?  I don't know, but there is one way to be sure.  Write it yourselves.  Meanwhile, the NICE guideline is still in consultation and if you are in the UK there is time to register as a stakeholder and send comments.

There is also one last chance to take part in the survey that is seeking to gain consensus on the factors that clinicians everywhere use as part of their rule-out process in ill children.  Please do take part.  It takes less than five minutes.


Edward Snelson
Simplologist
@sailordoctor

Disclaimer: Simple is easy when you're not actually writing the guidelines.


References

  1. Sepsis - NICE guideline in development (closing date for comments 22nd Feb 2016)
  2. Green et al., Admission to hospital for bronchiolitis in England: trends over five decades, geographical variation and association with perinatal characteristics and subsequent asthma, Arch Dis Child doi:10.1136/archdischild-2015-308723






Thursday, 7 January 2016

The Trouble with Training (Easter egg - when to do a Chest X-ray in children in the ED or General Practice)

I remember well how difficult it is to stay up to date across the thousands of clinical scenarios that face the General Practitioner.  When I was faced by something not in the top 100 weekly problems, I usually had to think back to my training.  That works well as long as what I recalled was accurate, and was best practice at the time and remained so.  What are the chances of all three being true even five years post-training?

Accurate recall (keep taking that thiamine) aside, the first issue is whether one's training involved the demonstration of standard care.  I was recently pulled into a twitter conversation about whether children with pneumonia required a chest X-ray (CXR).  The person facilitating the discussion was one of the local GP trainers who had himself been asked by one of the GP trainees here in Sheffield.  The trainee felt that they were getting mixed messages and wanted to know the right answer.  Of course a complete answer doesn't fit in a tweet.  Also, tweets are transient unless they are the kind that get you fired.  So a GPpaedsTips post seems to me to be the best place for a proper answer.  Since the question was about acute paediatrics, I can legitimately put a foot outside of the Primary Care remit of this site, but it seems the ideal opportunity to also address the question of when a CXR might be indicated for a child in a General Practice setting.


Continuing with the theme of see one do one, lets start with children with pneumonia in a secondary care setting in the UK.  The British Thoracic Society guidelines for community acquired pneumonia in children are, in my opinion, very good.  Their recommendation that "Chest radiography should not be considered a routine investigation in children thought to have community acquired pneumonia" is based on the old principle of 'if it doesn't change your management don't do it.'  Putting that into practice requires a little step back and for us to ask the question, 'what is a CXR for?'  I used to think it was needed to diagnose pneumonia.  That is a fallacy, since X-ray changes will have a time lag and a CXR can be a false negative.  So, is it to show the severity, or what kind of pneumonia it is?  No, the severity is a clinical assessment and the type of chest infection is determined by a combination of the clues in the assessment and the response to treatment.  According to the BTS guidelines, CXR in the ED or paediatric assessment unit should mainly be used for the cases which are a little bit different from the routine LRTI.  This might be repeated LRTI, a child who is severely unwell or a number of other reasons.  That doesn't mean find a reason.  It means find a good reason.  In particular, if you think the child is well enough to treat as an outpatient, BTS recommends never doing a CXR.  Never is a strong word but it's a good place to start and puts the GP CXR question in context.


Adults, with their risk of lung cancer, are different.  In children, signs and symptoms are usually all you need when making decisions about treatment or referral when it comes to children's respiratory problems.  In my opinion, doing a CXR for a child in primary care should be for a situation where the X-ray could give information that allows treatment to be given or a referral to be avoided.  I can't think of any situations where the CXR would do that but a history and examination would not.

I understand that one reason that CXRs are done for children in Primary Care is to reassure parents or clinicians.  I would be very wary of that plan.  CXRs often have findings on them, especially when a child has a viral illness.  A finding is not the same thing as a clinically significant abnormality, but it is not very reassuring either.


Then there is the possibility that a CXR might be done in the belief that one would be done for the same patient in a hospital setting.  That is also tricky since practices change.  The trouble is that they may change slowly and inconsistently.  I believe that the safest approach is to avoid second guessing what tests someone else will want.  I either ask them or leave them to request their own investigations.


So then there is the challenge of being up to date.  I would like to use this opportunity to tell all my secondary care colleagues how stupidly easy we have it in this regard.  The environment we work in continually provides us with updates and learning (if you are surrounded by the kind of clever yet pragmatic clinicians I work with).  I remember how General Practice is a relatively isolated learning environment and how difficult it is to keep abreast of changes in so very many areas.

That's the trouble with training and keeping up to date: these things have the tendency to look fun and manageable but actually have the tendency to expand exponentially and take over.  Meanwhile, we all have a ship to run. The solution: Cling on, outsource your troubles and let FOAMed give you the answers.

Snelson out


Disclaimer: I need reassurance too. I'm just not sure where to find it any more.

Reference:
BTS guideline for Community Acquired Pneumonia in Children

Thursday, 21 May 2015

Referrals – Inappropriate, Inconvenient or Unprofessional? (Easter egg - umbilical granuloma)


But first: why the hospital doctor who thinks that they have had an inappropriate referral probably has an educational need.

Every day, around the world, there is tutting by hospital doctors about the inappropriate referrals that they receive from primary care.   If we assume that both clinicians believe in good patient care and the best use of resources then someone must have an educational need for this situation to take place.  My question is: who has that need?

Let’s take a fictional yet real example: a baby with an umbilical granuloma.  The child has apparently been sent to the paediatric emergency department by the clinician who saw them in Primary Care.  The emergency department doctor sees the child, noting the inappropriate use of the ED to filter referrals from a GP.  They complain but accept their lot and assess the child but then send the child back to the GP.

Imagine that we could get the two clinicians to sit down and discuss what happened.  What the GP trainee who saw the child would say was that they thought that the child had an infection of their umbilicus, which they know to be a risk for sepsis in babies.  They tried to refer the child but they were passed back and forth between the paediatricians on call who said that this was a lump and therefore surgical, while the surgeons said that umbilical infections should be referred to the paediatricians.  In the end there was confusion and in the process both teams thought that the other had accepted it and the faxed letter from the GP never found an owner.

So the ED doctor might have been more sympathetic and less likely to say that the ‘referral’ was inappropriate when they found out that it was not a referral.  What the GP trainee might have learned is that umbilical granulomas often have a degree of discharge and look messy but that doesn’t equal infection.  They may have been interested to know that many clinicians are adopting a ‘leave it alone’ approach to umbilical granulomas since they have a natural tendency to resolve. (1) Some advocate hypertonic saline (2) as a topical treatment but ultimately if left alone, these unsightly lumps will go away if you ignore them for long enough.  Most will welcome the move away from the game of ‘hit the moving target with a silver nitrate stick’ while hoping that there is no accidental application onto healthy skin.



Lets hope that the joint RCPCH and RCGP document 'Facing the Future Together' with its 11 recommendations will provide an impetus for better communication between primary and secondary care.  I am particularly hopeful that point 4 becomes a reality because educational meetings can work both ways.

Facing the Future together: The first four standards-


So whenever something seems ‘inappropriate’, it may be a misunderstanding or there may be a genuine opportunity to share something between two professionals.  I accept that there are GPs who don’t care about inconveniencing patients or overloading their local emergency department but these are a vanishingly rare breed.  More often, if I get in touch to clear something up that is exactly what happens and I am just as likely to be the one set straight.  The important thing is to talk to each other and not about each other.  That really would be inappropriate.

Edward Snelson
Naturalised Citizen of the People's Republic of South Yorkshire
@sailordoctor #GPpaedsTips

Easter egg - for more on umbilical granuloma follow the links below


  1. Umbilical granulomas: a randomised controlled trial J Daniels, F Craig, R Wajed, M Meates Arch Dis Child Fetal Neonatal Ed 88:F257 doi:10.1136/fn.88.3.F257 http://fn.bmj.com/content/88/3/F257.1.full

  2. www.banglajol.info/index.php/BJCH/article/download/10360/7648  BANGLADESH J CHILD HEALTH 2010; VOL 34 (3): 99-102 Therapeutic Effect of Common Salt (Table/ Cooking Salt) on Umbilical Granuloma in Infants AKM ZAHID HOSSAIN, GAZI ZAHIRUL HASAN, KM DIDARUL ISLAM

Disclaimer: All the opinions expressed here are someone else's.